Pattern and prevelence of alloimmunization in multiply transfused patients with sickle cell disease in Nigeria
نویسندگان
چکیده
منابع مشابه
Red cell alloimmunization in multi-transfused patients with sickle cell anemia in Benin City, Nigeria.
BACKGROUND Sickle cell anemia (SCA) is an inherited hemoglobin disorder characterized by chronic anemia and occasional crises. Clinical features are variable. While some individuals are relatively stable and rarely require blood transfusion, others often require blood transfusion. Multiple blood transfusion is associated with complications including alloimmunization, infections, and iron overlo...
متن کاملPattern of chronic lung lesions in adults with sickle cell disease in Lagos, Nigeria
Background: The vascular response to recurrent tissue hypoxia and reperfusion following red blood cell sickling causes acute chest syndrome and chronic lung disease. The purpose of this study was to determine the pattern of chronic lung lesions and possible risk factors in sickle cell patients in lagos, Nigeria.Methods: From July 2012 to April 2013, Pulmonary function test (PFT) and chest-x-ray...
متن کاملAlloimmunization to platelets in heavily transfused patients with sickle cell disease.
Bone marrow transplantation (BMT) is now an option for some patients with sickle cell disease (SCD). Many SCD patients are multiply transfused with red blood cells (RBCs), and may be immunized to alloantigens other than erythrocyte antigens. Because platelet refractoriness is a significant complication during BMT, we wished to determine the prevalence of alloimmunization to platelets in transfu...
متن کاملAlloimmunization in Patients with Sickle Cell Disease in French Guiana
This study in French Guiana assessed the frequency of alloimmunization to red cell antigens in sickle cell disease patients over 1995-2011 and identified the most common antibodies. A retrospective analysis of the transfusion history and medical records of 302 patients showed that 29/178 transfused patients had developed alloantibodies (16%). The most frequent alloantibodies were anti-LE1, anti...
متن کاملRed cell alloimmunization in repeatedly transfused patients
INTRODUCTION Repeated blood transfusions can result in the production of alloantibodies against one or more red cell antigens, which complicates subsequent transfusions. Aims: The study was done to find incidence of various red cell alloantibodies; to determine the type of alloantibody; to identify the factors such as frequency of transfusion, splenectomy status, donor ethnicity and gender and ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biomarker Research
سال: 2015
ISSN: 2050-7771
DOI: 10.1186/s40364-015-0050-3